Protease Inhibitors and Phosphatase Inhibitors
American Research Products Inc ALKALINE PHOSPHATASE KIT COLOR
5000265296 ALKALINE PHOSPHATASE KIT COLOR
Ubpbio A 58 amino acid small protein that is a potent serine protease inhibitor. CAS# 9087-70-1, ≥3.0 EPU/mg
Aprotinin is a 58 amino acid small protein derived from bovine lung tissue that is highly positively charged and contains three disulfide bonds. It is a competitive inhibitor of several serine proteases, including trypsin, chymotrypsin, thrombin, and plasmin. In clinical, it is used as an anti-clotting agent for reducing bleeding. This product is for research use only. Typical working concentration is 2 µg/ml.
Cayman Chemical IKK2 InhIbItr VI 500ug
A potent, cell-permeable, reversible inhibitor of IKK2 (IC50 = 13 nM); used to evaluate the role of the canonical, IκB-dependent NF-κB signaling pathway in cellular responses
American Research Products Inc Mouse Serine protease HTRA1 H
Mouse Serine protease HTRA1 (HTRA1) ELISA kit from CUSABIO Detection Range 78 pg/mL-5000 pg/mL Sensitivity 19 5 pg/mL Sample serum plasma tissue homogenates Method Sandwich
Cayman Chemical mP-13 InhIbItr 10mg
A pyrimidine dicarboxamide that selectively inhibits MMP-13 (IC50 = 8 nM); blocks osterix-dependent calcification of matrices in limb bud cells during endochondral ossification
Invivogen BAY 11-7082 | 19542-67-7 | MFCD00712162 | 10 mg
BAY 11-7082 | Purity: 95% | Mol Wt: 207.25 | 19542-67-7 | MFCD00712162 | 10 mg
Ubpbio MG-132, 5MG
Inhibitors – MG-132 (UBPBio catalog# F1100, F1101, F1102) – MG-132 is a reversible proteasome inhibitor that belongs to the family known as peptide aldehydes. MG-132 is cell permeable and can be used to treat various mammalian cells to block proteasome activities. MG-132 can be dissolved in DMSO for stock solution up to 20 mM. The typical concentrations for cell culture use are 1-10 µM. For in vitro use, the typical concentrations are 50-100 µM. CAS#: 133407-82-6
Apexbio Technology LLC Protease Inhibitor Cocktail (EDTA-Free, 100X in DMSO), 1ml x 50
Equivalent to Sigma P8215, for use with fungal and yeast extracts to increase protein stability. Other sizes are available. Please inqury us for quote.
Apexbio Technology LLC Calpain Inhibitor I, ALLN(Synonyms: ALLN, N-Acetyl-Leu-Leu-Nle-CHO, Ac-LLnL-CHO, Calpeptin, MG101, CI-I), 25mg, CAS: 110044-82-1.
Calpain Inhibitor I (ALLN CAS 110044-82-1) is a potent inhibitor of calpain I (Ki 190 nM) calpain II (Ki 220 nM) cathepsin B (Ki 150 nM) and cathepsin L (Ki 500 pM) It enhances TRAIL-mediated apoptosis in DLD1-TRAIL/R cells as indicated by pronounced activation and cleavage of caspase-8 and caspase-3 while minimally cytotoxic on its own In vivo studies in Sprague-Dawley rats demonstrate reduced ischemia-reperfusion injury markers including decreased neutrophil infiltration lipid peroxidation adhesion molecule expression and I B- degradation highlighting its potential in inflammation research
Medchemexpress LLC 9,12-Epoxy-1h-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i]benzodiazocine-10-carboxylic acid | 126643-37-6 | 100 UG
KT5823 is a selective cGMP-dependent protein kinase (PKG) inhibitor with a Ki value of 0.23 μM, also inhibiting PKA and PKC. This staurosporine-related protein kinase inhibitor increases thyroid-stimulating hormone-induced NIS expression and iodide uptake in thyroid cells. It arrests cells after the G0/G1 boundary and causes increases in apoptotic DNA fragmentation.
- Arrests HSF55 cells in the G0 or G1 phase of the cell cycle.
- Induces dose-dependent increases in apoptotic DNA fragmentation in unstressed HRE-H9 cells.
- Enhances 8-pCPT-cGMP-induced VASP phosphorylation in human platelets.
- Blocks ameliorating effects of high-dose Bay 60-7550 in Aβ1-42-treated mice on memory.
Apexbio Technology LLC Phosphatase Inhibitor Cocktail (2 Tubes, 100X), (1ml A + 1ml B)50
K1012+K1013 Other sizes are available. Please inqury us for quote.
TARGETMOL CHEMICALS INC CYT-PTPEPSILON INHIBITOR 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Cyt-PTP(epsilon) Inhibitor-1 (A Inhibitor-1) is an inhibitor of cytosolic protein tyrosine phosphatase (epsilon). Cyt-PTP(epsilon) Inhibitor-1 blocks the dephosphorylation of c-Src and exhibits anti-osteoclastic activity. purity: 98%
Echelon Biosciences Research Labs PI 3-Ka Inhibitor 2 5 mg
3-(4-Morpholinothieno[3,2-d]pyrimidin-2-yl)phenol is a selective inhibitor for the -isoform of PI 3-Kinase (IC50: PI 3-K = 2 nM, PI 3-K = 16 nM, PI3-K = 660 nM, PI3KC2 = 220 nM)). It showed >1000-fold selectivity vs. protein kinases such as PKA, KDR, PKCa, and E/CDK2 (IC50 = 91, 3.4, 466, 288 M). It inhibited proliferation of A375 melanoma cells at 580 nM. This item is non returnable
Apexbio Technology LLC Tie2 kinase inhibitor 948557-43-5 5mg
Tie2 kinase inhibitor (CAS 948557-43-5) is a selective and reversible small-molecule inhibitor targeting the Tie2 receptor tyrosine kinase a critical modulator of endothelial cell survival angiogenesis and vascular integrity By inhibiting Tie2 autophosphorylation this compound disrupts subsequent signaling pathways involved in endothelial maturation and tumor-associated angiogenesis In vitro studies demonstrate potent inhibition of Tie2 kinase activity (IC50 0 25 M) with substantial selectivity over other kinases including p38 In vivo treatment reduces angiogenesis and tumor progression in murine xenograft tumor models This inhibitor is thus relevant for research examining angiogenic mechanisms and cancer progression